Week 5 NFL odds, predictions: SportsLine's model reveals picks

The Week 5 NFL schedule is the first with byes, meaning there are fewer contests to make Week 5 NFL bets on than before. That also means you can devote more time, energy and resources to these matchups, which include a number of inter-conference affairs. Jets vs. Cowboys (-2.5), Broncos vs. Eagles (-3.5), Bengals vs. Lions (-10.5) and Chargers vs. Commanders (+3) are some of the AFC vs. NFC games to place Week 5 NFL predictions on.

There is just one divisional game on Sunday and it sees the Bills hosting the Patriots (+7.5) on Sunday Night Football. Some may prefer making Week 5 NFL picks on common matchups like this one, or the rarer non-conference contests could drum up more interest with NFL betting. All of the updated Week 5 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 5 NFL picks now.

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, it has turned its attention to the latest Week 5 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick.

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Top Week 5 NFL predictions

We can tell you one of the model's strongest Week 5 NFL picks is that the Saints (-1.5, 41) cover the spread versus the Giants in a Sunday 1 p.m. ET kickoff. Jaxson Dart picked up a win in his first start, but the Giants also lost their best offensive player in losing Malik Nabers for the season. New York had just 89 team passing yards on Sunday, while the team averaged 243.3 passing yards with Russell Wilson under center. Even with the boost that Dart provided, New York still struggles immensely on the other side of the ball, ranking 30th in both total defense and run defense.

It's that run defense which could be an issue in the Superdome as the Saints have a top-10 rushing offense. The Saints are coming off covering versus the Bills in which three different players had at least 49 rushing yards, and New Orleans had 189 yards on the ground as a team. The Saints have also racked up three-plus sacks in three of four games this year, while Dart was taken down five times in his starting debut. The model projects New Orleans to have four QB takedowns as it stifles New York's offense, allowing the Saints to cover at home nearly 60% of the time. See which other teams to pick here.

Another one of its Week 5 NFL predictions: Cardinals (-7.5 41.5) cover versus Tennessee in nearly 60% of simulations. Arizona will have some extra rest after playing last Thursday, and no one has performed better versus the spread against non-conference opponents. The Cardinals have covered in seven straight games versus the AFC, while Tennessee is 0-6 ATS versus the NFC since the start of last season. The Titans have dropped three straight overall versus the spread, meaning they've picked up where they left off last year as their 3-18 spread record since 2024 is the worst in the NFL.

Tennessee was shut out, 26-0, by the previously winless Texans on Sunday, as the Titans have lost 10 straight games overall. They rank last in both points scored and yards gained, while sitting 26th in points allowed and yards allowed. Arizona has the No. 5 scoring defense and the No. 8 run defense, which could make the Titans overly rely on top pick Cam Ward. However, he just posted both his lowest passer rating and completion percentage as he's yet to throw a touchdown in two road starts. The model also says the Over hits nearly 70% of the time. See which other teams to pick here.

How to make Week 5 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 5 NFL schedule and just revealed four coveted A-rated spread picks, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.

So what Week 5 NFL picks can you make with confidence, and which four teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 5 NFL betting odds, lines, live spreads, scores

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