2025 Week 2 NFL score predictions, odds, best picks today: Expert reveals exact scores for every matchup

The Week 2 NFL schedule has arrived with 16 more games, most of which are projected to come down to one score. Fifteen games have a spread of 6.5 points or fewer, with only the Ravens (-11.5) vs. the Browns outside of that range. NFL bettors frequently target spreads, totals and money-line NFL picks. Some key Week 2 NFL odds include the Steelers at -3 versus the Seahawks, the Broncos at -1.5 against the Colts, and the Eagles at -1.5 versus the Chiefs in a Super Bowl rematch on Sunday. The Niners, who won't have Brock Purdy (toe, shoulder) or George Kittle (hamstring) are perhaps the team with the most injury questions this week, but they are still -3 against the Saints after opening at -7.

A set of exact Week 2 NFL score predictions can give you the tools needed to make a variety of picks for every game, as well as a guide for some NFL props you could target as well. Hitting on an exact NFL score prediction could also result in a huge payday. Before making any Week 2 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

A SportsLine expert and host, Cohen is evaluating the entire Week 2 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight-up NFL betting picks (69%) and was profitable for bettors. He's 12-4 on straight-up picks following Week 1 this season. Anyone who followed Cohen's NFL predictions has been profitable at their favorite sports betting sites and betting apps. You can only see Cohen's Week 2 NFL exact score predictions at SportsLine.

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Top Week 2 NFL picks

After diving into all 16 games from the NFL's Week 2, Cohen likes the Cowboys (-5.5, 44.5) to get their first win of 2025 with a home victory over their NFC East rivals, the Giants. New York coach Brian Daboll has committed to starting Russell Wilson at quarterback again, and Cohen believes that could cost New York again in Week 2 after he played poorly in Week 1. While he's taking the Cowboys to win, he likes the Giants to stay within the spread, and the over (44.5) to hit as well.

"I'm not quite sure why coach Brian Daboll didn't pull the plug on the Russell Wilson experiment after Week 1," Cohen told SportsLine. "The sooner New York can play rookie Jaxson Dart at QB, the better for New York's offense long term. Maybe Wilson is at risk for an in-game benching on Sunday? I'm going to predict that happens and the Giants stage a late comeback in the second half but fall short. I strongly lean Dallas to win at home but I'd be hesitant to lay the six points. Cowboys 27, Giants 23." See his other Week 2 football score predictions at SportsLine.

How to make Week 2 NFL score predictions

In addition, Cohen is completely fading one contender, saying it has "major problems in the interim." You can see who it is at SportsLine, and use promo code CHAMPIONSHIP to get your first month at SportsLine for just $1.

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