Syracuse vs. Colgate betting odds and prediction for Week 3 revealed ahead of Friday kickoff

Syracuse will look to shake off its 1–1 start when it welcomes Colgate to the JMA Wireless Dome on Friday night. The Orange enter as massive 37.5-point favorites, per FanDuel, and history is squarely on their side—the program hasn’t lost to the Raiders since 1950, winning 17 straight in the series. That dominance includes a 65-0 rout in the 2023 season opener, when seven different Syracuse players reached the end zone.

Colgate, meanwhile, brings a new era under first-year head coach Curt Fitzpatrick, who was hired after a decorated run at Division III Cortland, where he won the 2023 national title. The Raiders opened this season with a win but will need to take a big step up against an ACC opponent that has consistently controlled this rivalry. Fitzpatrick’s spread offense and quarterback background could help Colgate manufacture some plays, but the gap in size and depth presents a steep challenge.

According to Dimers.com’s 10,000 game simulations, Syracuse has a 98% chance of winning Friday’s matchup, with a projected final score of 50–13. While the Orange should have no trouble securing the result, the real intrigue comes from whether Syracuse covers the spread and how much the offense opens up after a cautious approach against Texas and Ohio. For the Orange, this is less about survival and more about building rhythm before conference play kicks in.

Colgate vs. Syracuse betting preview

Explore the interactive widget below to view the current spread, total, and moneyline odds and probabilities for the Colgate-Syracuse game at JMA Wireless Dome.

This prediction and best bet for Friday’s college football matchup between Colgate and Syracuse is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Colgate vs. Syracuse college football game.

Teams: Colgate vs. Syracuse

Date: Friday, September 12, 2025

Kickoff: 7 p.m. ET

Location: JMA Wireless Dome

NCAAF rankings: Updated AP Top 25

College football news: Check the latest updates from the official NCAA football news site

Odds

The latest and best odds for the college football battle between the Colgate and Syracuse.

Spread: Colgate +37.5 (-110), Syracuse -37.5 (-110)

Moneyline: Colgate +6500, Syracuse -100000

Total: Over/Under 66.5 (-110/-110)

The odds and lines presented in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

Please note that in New York, you cannot bet on in-state college teams. This applies to both home and road games. That said, you can bet on college teams from schools located outside of the state.

Promos

Note: Fans in New York can claim the FanDuel promo code to get exclusive sports betting deals.

Expert prediction: Colgate vs. Syracuse

Utilizing state-of-the-art data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Friday’s Colgate vs. Syracuse game.

According to Dimers’ independent predictive analytics model, Syracuse is more likely to defeat Colgate at JMA Wireless Dome. This prediction is based on the model giving Syracuse a 98% chance of winning the game.

Furthermore, Dimers predicts that the bookmakers have gotten it right and Colgate and Syracuse each have a 50% chance of covering the spread, while the 66.5-point over/under has a 56% chance of going over.

These predictions and probabilities are accurate at the time of publication but are subject to potential changes.

Colgate vs. Syracuse best bet

Our top pick for the Colgate vs. Syracuse game on Friday is to bet on Over 66.5 points (-110).

This betting advice is based on cutting-edge modeling and valuable betting intelligence, designed to help you make smarter decisions.

Score prediction for Colgate vs. Syracuse

Dimers’ projected final score for the Colgate vs. Syracuse game on Friday has Syracuse winning 50-13.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

College football Week 3: Colgate vs. Syracuse

Get ready for Friday’s college football matchup between Colgate and Syracuse at JMA Wireless Dome, which is scheduled to start at 7 p.m. ET. We emphasize that all of the college football predictions and college football best bets on this page are based on 10,000 data-driven simulations of the Colgate vs. Syracuse game, and they are accurate at the time of publishing. They aim to help you make more informed choices when placing bets at online sportsbooks.

Please note that when engaging in online betting, it is important to exercise responsible gambling practices and consult reputable sources for accurate and up-to-date information.

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