Arizona Cardinals vs Seattle Seahawks score updates for NFL Week 4

The Arizona Cardinals continue their 2025 NFL regular season schedule with an NFL Week 4 game against the Seattle Seahawks today.

The Cardinals are coming off a 16-15 loss against the San Francisco 49ers in their NFL Week 3 game. The Seahawks beat the New Orleans Saints in the third week of the season, 44-13.

The Cardinals lost both games against the Seahawks, an NFC West division rival, last season.

Follow our live updates of the game, which is being played at the Cardinals' State Farm Stadium in Glendale, Arizona, for the latest score, news, notes and analysis of the Week 4 NFL game on Thursday, Sept. 25.

The Seahawks and Cardinals are tied 20-20 in the fourth quarter.

NFL Week 4 picks: Seahawks at Cardinals | Vikings vs Steelers | Commanders at Falcons | Saints at Bills | Browns at Lions | Titans at Texans | Panthers at Patriots | Chargers at Giants | Eagles at Buccaneers | Colts at Rams | Jaguars at 49ers | Ravens at Chiefs | Bears at Raiders | Packers at Cowboys | Jets at Dolphins | Bengals at Broncos | The Republic's score predictions

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Cardinals tie game vs Seahawks with late touchdown

The Arizona Cardinals have tied this game.

Kyler Murray connected on a 7-yard pass to Emari Demercado for the score with 28 seconds left to tied this game and make State Farm Stadium go nuts.

The Cardinals had a second & goal at the Seattle 7 after Emari Demercado ran up the middle for no gain after an 18-yard catch from Marvin Harrison Jr.

Demercado's touchdown came on third down.

Score: Cardinals 20, Seahawks 20 (:28 left in fourth quarter)

Cardinals call timeout late vs Seahawks

The Cardinals got a 15-yard reception from Greg Dortch and then a 5-yard reception from Marvin Harrison before Kyler Murray threw it incomplete to Trey McBride, setting up a 3rd & 5 at the Seattle 25.

Arizona had to call a time out with the play clock running down, giving the team one left with 1:16 remaining.

Cardinals extend drive with Michael Wilson catch on fourth down

On 4th & 4 at the Arizona 49 with 3:01 left in the fourth quarter, Michael Wilson caught a pass from Kyler Murray with one hand to extend the Cardinals' possession.

We are at the 2-minute warning and the Cardinals face a 3rd & 9 at the Seattle 45.

Cardinals keep hope with missed Seahawks' field goal

The Arizona Cardinals are still in this game.

Jason Myers just missed a 53-yard field goal wide right to keep this a one possession game.

On 3rd & 6 at the Seattle 26, Sam Darnold passed it to Jaxon Smith-Njigba for 36 yards to extend the drive for Seattle and eat more clock for the Seahawks, who went seven plays for 43 yards on the drive.

The drive took 2:34 off the clock.

Kyler Murray connects with Marvin Harrison Jr. for touchdown vs Seahawks

The Arizona Cardinals have made this a one-possession game.

Kyler Murray just connected on a 16-yard touchdown pass with Marvin Harrison Jr. to make it a 20-13 game and get the Cardinals' crowd into this game.

And give Marvin Harrison Jr. some much-needed confidence after his recent struggles.

The Cardinals' drive went for 73 yards over eight plays.

The key play (besides the touchdown)? A pass interference call on Seattle defending Xavier Weaver, which gave the Cardinals a 1st & goal at the 9-yard line.

Kyler Murray also had a 29-yard run on the drive.

Score: Seahawks 20, Cardinals 13 (5:50 left in fourth quarter)

Cardinals' defense makes big stand vs Seahawks

The Seahawks just kicked a field goal to extend their lead, but it could have been worse.

Seattle had a 1st & goal at the Arizona 7, but the Seahawks' Jaxon Smith-Njigba was called for holding on a play, negating a Zach Charbonnet TD run on the drive.

Smith-Njigba was not happy about the call, appearing to talk back to the official about it and getting caught on an open mic as the official was announcing the penalty.

Jason Myers hit a 31-yard field goal to end the 14-play, 53-yard drive for the Seahawks and make it a 20-6 game.

But it is still just a two score game, although the Cardinals, who haven't been able to get into the end zone all night, would have to get into the end zone twice to tie the Seahawks.

Score: Seahawks 20, Cardinals 6 (9:33 left in fourth quarter)

Arizona Cardinals get first points of second half vs Seattle Seahawks

The Cardinals' next possession wasn't pretty, but it did end with the team getting points.

Chad Ryland hit a 57-yard field goal with 1:39 left in the third quarter to make it a 17-6 game.

Arizona had a 1st & 10 at the Seattle 32 before the drive stalled and included the Cardinals attempting a flea flicker that the Seahawks were all over.

Marvin Harrison Jr. did have a 16-yard catch on the possession.

Score: Seahawks 17, Cardinals 6 (1:39 left in third quarter)

Seahawks held to 3-and-out vs Cardinals

The Cardinals' defense just stepped up, forcing a 3-and-out by Seattle, with the Seahawks just gaining one yard on three plays.

Sam Darnold is now 12-for-16 for 149 yards and a touchdown pass for Seattle.

Arizona gets to start its next drive at its own 35-yard line, desperately seeking a spark.

Arizona Cardinals punt on first possession of second half of Thursday Night Football

The Cardinals have now punted four times in this game after having to punt on their first possession of the second half.

Arizona's best offense on the drive? It gained 14 yards on a pass interference penalty on Seattle.

The Cardinals have 115 yards in this game. Kyler Murray is 15-for-25 for 86 yards, with two passes intercepted.

Fans continue to boo the team.

Can you blame them?

Seahawks extend lead with field goal vs Cardinals to start second half

The Cardinals once led this game, 3-0.

But after the Seahawks just hit a field goal on their first possession of the second half, the score of this game is now Seahawks 17, Cardinals 3, with Seattle having scored 17 unanswered points.

Jason Myers connected on a 44-yard field goal to extend the Seahawks' lead and the 17 points might be enough to win this game if Kyler Murray and the Cardinals can't get anything going on offense.

Score: Seahawks 17, Cardinals 3 (8:56 left in third quarter)

Can Cardinals get Marvin Harrison Jr. going in second half?

Marvin Harrison Jr. had a terrible first half for the Cardinals, with one catch for eight yards, which came on the first play of the game.

He was targeted five times.

On one of the targets, he bobbled a ball, resulting in the Seahawks intercepting Kyler Murray's pass.

Can the Cardinals get Harrison Jr. going in this game? He has struggled this season.

Arizona really needs some explosive plays and something to get the team and the crowd fired up. With the running game struggles, perhaps Harrison Jr. can make a play or two to get the Cardinals' offense on track.

Arizona Cardinals trail Seattle Seahawks at halftime of Thursday Night Football

30 minutes have been played at State Farm Stadium for the Cardinals vs Seahawks game.

The first 30 minutes was all Seattle.

The Cardinals were just booed as they ran off the field at halftime, trailing the Seahawks on Thursday Night Football, 14-3.

Arizona has been outgained in this game, 211-94. It is allowing Seattle to average 7.5 yards per play.

The Cardinals have definitely missed James Conner, who was lost for the season with an injury last week. Arizona has eight rushing attempts for 35 yards in the game.

Seattle has 17 carries for 95 yards, with a 1-yard run for a touchdown from Zach Charbonnet.

Sam Darnold was 8-for-11 for 123 yards for the Seahawks in the first half, with one passing touchdown. The Cardinals' Kyler Murray was 12-for-19 for 67 yards, with two passes intercepted.

Seattle will receive the ball to start the second half.

Halftime score: Seahawks 14, Cardinals 3

Seattle Seahawks extend lead vs Arizona Cardinals on Zach Charbonnet run

We just mentioned explosive offensive plays and the Cardinals' inability to make them.

Seattle didn't have that problem on their latest possession. Among them?

Sam Darnold connected on a 32-yard pass to Elijah Arroyo.

Darnold ran for 24-yard yard gain.

Zach Charbonnet ran for a 15-yard gain.

Charbonnet had a 1-yard touchdown run on the drive to extend the Seahawks' lead before the half.

Budda Baker was called for pass interference in the end zone on the drive, setting up the Seahawks at the 1-yard line.

Score: Seahawks 14, Cardinals 3 (1:01 left in second quarter)

Arizona Cardinals go 3-and-out again vs Seattle Seahawks

The boo birds are out at State Farm Stadium

The Cardinals were just booed by fans after going 3-and-out against the Seahawks.

Arizona got a 4-yard run from Greg Dortch on the first play of the possession, then Trey McBride had a 4-yard reception from Kyler Murray.

Michael Carter only managed to gain one yard on 3rd & 2 at the Arizona 28, forcing the Cardinals to punt.

Arizona fans are growing increasingly frustrated with the team's offense (or lack thereof). This offense just hasn't been able to generate any explosive plays.

Kenneth Walker III taunting penalty stalls Seahawks drive vs Cardinals

Kenneth Walker III just received a 15-yard taunting penalty for throwing the ball back at the opposition, which ended Seattle's momentum on the drive when they had been at the Arizona 28.

Seattle had to punt after six plays.

Walker III has eight carries for 46 yards in the game.

Marvin Harrison Jr. dropped pass results in Kyler Murray interception vs Seahawks

Marvin Harrison Jr. has been under the microscope for his dropped passes and struggles for the Arizona Cardinals.

The focus on Harrison Jr. is only going to get more intense after the latest play for the Cardinals.

Harrison Jr. bobbled a pass from Kyler Murray on a 3rd & 11 at the Seattle 33, with the pass betting intercepted by Ernest Jones IV at the Seattle 22. Jones was able to run back to the Arizona 49.

Ouch.

The interception ended Arizona's drive, which was its most impressive of the night until that point.

Cardinals' defense gets big sack from Calais Campbell to force Seahawks punt

The Cardinals didn't allow Seattle to get a long drive this time.

The Seahawks managed to gain three yards on six plays before being forced to punt.

Arizona got a big sack on Sam Darnold on 2nd & 12 to help end Seattle's drive, with Calais Campbell tackling Darnold for a 7-yard loss.

Now, can Arizona's offense step up?

Cardinals' offensive woes continue vs Seahawks

The Cardinals' offense continues to struggle.

Arizona just had to punt after a three-and-out.

Kyler Murray was sacked for an 8-yard loss to set up a 3rd & 15 on the possession.

Arizona has not been able to get much going in this game. It was outgained in the first quarter, 115-49.

Offensive coordinator Drew Petzing and company need to get something going quick to stop Arizona's offensive struggles.

Seahawks take first lead on Cardinals on Thursday Night Football

Sam Darnold just threw a perfect pass to AJ Barner for a 16-yard touchdown pass to give the Seahawks their first lead of the game.

The Seahawks drove 77 yards over nine plays for the score, with Darnold finding Barner for the touchdown.

The touchdown was set up by an 11-yard pass from Darnold to Cooper Kupp on 3rd & 2 at the Arizona 27.

Darnold is now 5-for-6 for 78 yards and the score.

Score: Seahawks 7, Cardinals 3 (1:33 left in first quarter)

Cardinals score first against Seahawks on Thursday Night Football

The Cardinals are on the board in Glendale. Arizona has a 3-0 lead on the Seahawks after a 32-yard field goal from Chad Ryland.

Arizona was able to drive down to the Seattle 10 after the Seahawks turnover before its drive stalled.

Kyler Murray is now 6-for-9 for 31 yards in the game.

Score: Cardinals 3, Seahawks 0 (4:37 left in first quarter)

Thursday Night football game features two turnovers on one play

Thursday Night Football seems to always feature some wackiness.

Two turnovers on one play certainly qualifies.

The Seahawks' Coby Bryant intercepted a pass from Kyler Murray, only to fumble it on the return when he was hit by a teammate, giving the Cardinals the ball back. Trey Benson recovered the fumble for Arizona.

Arizona started the play at its own 48. It got the ball back at the Seattle 47.

Seattle's defense thought they had the ball and went clear down to the end zone to celebrate, adding to the wackiness.

Cardinals defense stops Seahawks on fourth down

The Cardinals' defense has come up with some big plays this season. It came up with a big play early on Thursday Night Football.

On 4th & 1 at the Arizona 48, Seattle's Zach Charbonnet was stopped for no gain, ending the Seahawks' first possession and giving the Cardinals great field position for their second.

The big play on the drive was a Sam Darnold pass to Kenneth Walker for 29 yards.

Arizona Cardinals forced to punt on first possession vs Seattle Seahawks

The Cardinals started their opening possession with an 8-yard pass from Kyler Murray to Marvin Harrison Jr., which was good news for Arizona as it tries to get the wide receiver involved.

But the Cardinals had to punt after getting just one first down on the drive.

The Cardinals' offense hasn't had a 300-yard game yet this season and tonight would be a great time to change that.

Arizona Cardinals, Seattle Seahawks announce inactives for Thursday Night Football game

Who is out for the Cardinals vs Seahawks game tonight?

The Arizona Cardinals' inactives include cornerback Will Johnson, wide receiver Zay Jones and offensive lineman Will Hernandez.

Safety Nick Emmanwori is among those out for the Seahawks today.

Trey McBride goes all in with sand look before Cardinals vs Seahawks game

Let's give Cardinals tight end Trey McBride some props for his attire before the Cardinals vs Seahawks game.

McBride arrived to the Thursday Night Football game at State Farm Stadium in sand attire, similar to what the Cardinals will be wearing tonight.

Here's some other pregame fits for the Cardinals.

Arizona Cardinals paint end zones in Arizona flags for Thursday Night Football

The Cardinals are going all in on the NFL Rivalries uniforms theme tonight.

Check out how they painted the end zones to match Arizona's jerseys.

Beautiful.

Seahawks vs Cardinals uniforms: What Seattle, Arizona are wearing on Thursday Night Football

The Arizona Cardinals will debut their new NFL Rivalries uniform on "Thursday Night Football" on Sept. 25, against the Seattle Seahawks at State Farm Stadium.

The Seahawks are wearing navy jerseys and gray pants.

Cardinals vs Seahawks schedule: What time is NFL Week 4 game?

The NFL Week 4 game between the Cardinals and Seahawks is on Thursday, Sept. 25 at 5:15 p.m. MST, 8:15 p.m. ET.

Seahawks vs. Cardinals TV: What channel is NFL Week 4 game on?

The Seahawks vs. Cardinals NFL Week 4 game can be seen on Prime Video.

Cardinals vs. Seahawks streaming: How do I watch NFL Week 4 game on livestream?

Streaming options for the Cardinals vs. Seahawks game include Amazon, the exclusive home of Thursday Night Football.

Seahawks vs. Cardinals announcers: Who is calling the NFL Week 4 game?

Al Michaels (play-by-play) and Kirk Herbstreit (analyst) are scheduled to be the announcers for the Cardinals-Seahawks Week 4 NFL game.

Cardinals vs. Seahawks game odds: Who is favored in NFL Week 4?

The Seahawks are a 1-point favorite over the Cardinals in NFL Week 4 odds for the game, courtesy of BetMGM Sportsbook.

Seattle is -115 on the moneyline, while Arizona is -105.

The over/under (point total) is set at 43.5 points.

Seahawks vs. Cardinals picks, predictions: Who will win NFL Week 4 game?

The Arizona Republic's Jeremy Cluff is predicting a 24-17 win for the Seahawks over the Cardinals in the Week 4 NFL game today.

Other sites lean toward the Seattle beating Arizona in their Cardinals vs Seahawks NFL Week 4 picks and NFL Week 4 predictions for Sept. 25.

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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